Gator

I suspect that it's more a "devil is in the details" kind of thing, but what do I know? I mean, we study aging in my lab, and I guess our findings that aging is bad are along the same lines lol.

This was originally my daughter's bow, and I love to see it getting used by our future hunters! When it comes to youth sporting goods, IMHO paying it forward trumps making a buck every time.

You might be able to engineer a skewing toward males like they're trying with Asian carp, but cross breeding is certainly an issue. I teach medical students about CRISPR/Cas9 gene editing, as we've used it in the lab now for over 15 years, and the final part of the lecture presents three myths: Myth 1: Current genome editing technologies are not error prone Myth 2: Precision equals control Myth 3: DNA functions are modular and changes are predictable I'd be more inclined to favor an approach where you genetically modify larval lamprey's food to express a double-stranded RNA that targets a lamprey-specific gene product through RNA interference. I think that might be the safest bet, but it still mucks about with playing God.

You guys are killing it! I almost gagged at the thought of "lamprey pie". Thanks to Pete for keeping us informed and up to date. And H2B - if I'm going to take on a "Slayer" title, I humbly request assignment to Sarah Michelle Gellar's squad. Okay, onto actual science. I read Mike Siefkes' 2017 review on established and emerging approaches to sea lamprey control https://pmc.ncbi.nlm.nih.gov/articles/PMC5448140/ and it made me wonder whether a combinatorial approach, using much lower doses of multiple chemicals together, might be the ticket. The current drugs are detoxified through different mechanisms, and the lamprey's inability to do so as effectively as other fish results in their relative susceptibility - albeit only ~8-10 fold over that of other fishes. When we run into a situation in the lab where we have a couple of chemicals that only exhibit <10-fold selectivity but are effective for different reasons, we can often combine them at way lower doses and get multiplicative effects. Hence, we benefit from less off-target effects (here, that would be killing other types of fish) and increased efficacy. I am going to reach out to Michael. I'm sure that this type of approach is being tested. But since mitochondrial function is exactly our area of expertise, it could be an interesting collaboration. Moreover since I'm retiring in a year of so, it would be a fun project to invest some time as things wind down, and with their funding issues, it might be that they could use some unsolicited aid moving forward.

And I'll help you!! Nothing prevents a scientist from getting his hands dirty. Or blistered, like Tommy used to make fun of me for back before he had floating docks and we needed to use the 40 lb sledge to drive the posts into the bottom of Sandy. Thank God we had a Duane.

Thanks, Pete. I think the article mirrors what most of us have observed. It seems like lamprey can be kept at bay but are never going to be eradicated - and there are some perhaps legitimate concerns emerging about dumping a nitrophenol into our water. The alternative, niclosamide, is a compound that I've used extensively in the lab; like nitrophenols, it dissociates mitochondrial substrate utilization from energy production, but we also employed it as a non-selective inhibitor for certain classes of calcium activated ion channels. Hence, in addition to the financial considerations that we've explored here, there are also other factors at play. These chemicals are undoubtedly the most effective and selective options for lamprey control, but selectivity is a funny thing... Regardless, it's good to keep up to date. Thanks again.

KK. Still, a great name for a boat.

Gill, I got to ask - do you work in law enforcement or as an attorney? I'm trying to figure out if Gill-T Hooker is a play on words. Our first boat's name was Wandering Seamen, so I'm a big fan of the double entendre, and I still love "No Balls" down at the Niagara.

Agreed. Maybe we aren't targeting them appropriately, but they're a unicorn for us. We caught 3 1/2 last year.

I can't believe the Nils isn't sold. If I didn't have both an 8" and 6" version already, I'd snap it up, particularly if the blade is in decent shape. Word to the wise - don't use a Nils on Braddocks. The sand in the ice eats the blade and then you got to send it to Frank Deluca to get sharpened. How do I know? Don't ask.

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I know where there's a bunch of them, on a boat right near yours. #airtagurreels #serial#smatter #natowireurgunnel

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Several items marked sold, but others still available.

Only a couple things left. The modem/router combo is current and retails for serious change. If this stuff is not sold by the weekend, it's going bye-bye. 1. Costa 580G Apalach with Tortise Frame. Near perfect condition. $50 - SOLD 2. Hobie glass lenses for a narrow face. $10 -SOLD 3. Native plastic lenses, narrow face. $0 4. Outboard motor lock. $10 SOLD 5. Truck steering wheel lock. $10 6. Wireless GPS module - works for iPad, etc.. $10 7. Muddy lumbar support for tree stands (x3). $20 total. SOLD 8. Browning waterproof, insulated bibs, large, great condition but elastic suspenders have some Ozone stretching lol. $25- SOLD 9. Guide series fishing vest. Large. Unused. $10 10. Hendrix Outdoors wading jacket. Gore Tex? Unused, large, neoprene cuffs. $25 - SOLD 11. Shooting vest. $0 12. Turkey vest with detachable seat. Great condition. $20 - SOLD 13. Netgear Modem/Router combo C7000 v2. Only two years old, but will NOT work with the new symmetric network Spectrum is rolling out (same upload and download speeds). $30.

I was actually out in my kayak until the wind picked up, but on the ponds rather than the lake. It looked great out there.

Somebody playing hooky lol? Nice morning, nice fish.

Awesome reporting, Pete. Thank you.

Nice pics! And Happy Birthday. I was torn yesterday between hitting the lake or Honeoye. Chose the later and didn't regret it